Abstract: Objective : To study the advantages and specific techniques of retroperitoneal laparoscopy andtransurethral resectoscope in total nephroureterectomy with bladder cuff excision for upper urinary tract transi-tional cell carcinoma. Methods : A total of 13 patients (4 males and 9 females, aged from 52 to 78 years) withtransitional cell carcinoma underwent radical nephroureterectomy and bladder cuff excision with retroperi-toneal laparoscopy and transurethral resectoscope between January 2006 and January 2008. Of the 13 cas-es, 7 had renal pelvic tumors (3 cases had tumor in the left kidney and 4 cases had tumor in the right kidney)and the other 6 cases had ureteral tumors (5 cases had tumor in the left ureter and 1 case had tumor in theright ureter). Two cases had tumors in both the ureter and the bladder. An electrode was used to incise thebladder 1.0 cm away from the ureterostoma. Electric coagulation was used to effectively stop bleeding andthe bladder was not irrigated. Then the operation was performed with a celioscope (30° or 0°). CO₂ was inject-ed into the retroperitoneal space and the celioscope was put into the retroperitoneal space to dissect the kid-ney and dissociate the ureter completely. Results : All of the patients were successfully treated without compli-cations. The total duration of surgery was 150~330 min, with an average time of 216 min. The duration oftransurethral bladder cuff excision was 20~50 min, with an average time of 30 min. Blood loss was 50 to 600ml. Postoperative vesicle irrigation was performed to prevent tumor recurrence. Postoperative pathologyshowed that the carcinoma was transitional cell carcinoma Ⅱ-Ⅲ, T₁N₀M₀or T₂N₀M₀. During the follow up of 2-30 months, one patient had tumor recurrence in the bladder and the other patients had no tumor recur-rence, metastasis or implantation. Conclusion : Radical nephroureterectomy and bladder cuff excision byretroperitoneal laparoscopy and transurethral resectoscope are effective treatments for transitional cell carci-noma, with minimal invasiveness, quicker recovery, fewer complications, complete excision of the ureter, and satisfactory disease-free and disease specific survival rates.