Abstract: Objective : To introduce a simple, safe and effective method for coverage of the soft tissue defect of thegroin and low abdominal wall. Methods : Four cases (3 males and 1 female), including 1 case of malignant fi-brous histiocytoma, 1 case of fibrous sarcoma, 1 case of angiosarcoma and 1 case of inguinal lymph nodesmetastasis of carcinoma of penis underwent multiple surgeries between September 2005 to December 2007.The average age was 69 (range 61-76). The surgical incision started from the medial upper cornu of the de-fect of the groin and low abdominal wall to xiphisterum along the median line of the body, then turned to theposterior line of axillary fossae passing below mammary areola. The medial margin of front sheath of rectusabdominis muscle was cut, the complex of front sheath of rectus abdominis muscle and connected oblique ex-ternal abdominis muscle with skin was lifted and a myofasciocutaneous flap of wide pedicel was formed.Then, the flap was moved to cover the defect of the groin and low abdominal wall. Exposed donor site was su-tured directly. The average area of defect was 310cm² (ranged from 18×15 to 18×22cm). The range of myofas-ciocutaneous flap transposition was from 30×17 to 37×20cm. All wounds were closed primarily, except 1 casewhich had a grafting area of 3×3cm area grafting. Result : All of the myofasciocutaneous flaps were success-ful, achieving primary healing in 3 cases and second-stage healing occurred in 1 case. All patients were fol-lowed up for an average period of 11 months. One case had recurrence and no ventral hernia was observed. Conclusion : Repairing the defect of the groin and low abdominal wall after tumor resection with myofasciocuta-neous flap of oblique external abdominis muscle is a simple, safe and effective method.