Abstract: Objective : To explore the significance of the expression of BCSG1 and Survivin and their correlation in in-vasive breast cancer. Methods : The expression of BCSG1 and Survivin were determined with the SP immuno-histochemistry in 100 samples of invasive breast cancer and 10 samples of normal breast tissues. Results :The expression rates of BCSG1 and Survivin were 65% (65/100) and 67% (67/100) respectively, and werecorrelated with cerbB-2 expression rate and lymph node metastasis ( P <0.05). The cerbB-2 expression wassignificantly lower than the concurrent expression rate of BCSG1 and Survivin (50%). Among patients withconcurrent expression of BCSG1 and Survivin but with negative cerbB-2 expression, 86.4% (19/22) werefound with lymph node metastasis, while patients without concurrent expression of BCSG1 and Survivin pre-sented with a rate of lymph node metastasis of 16.7% (3/17), with a significant difference ( P <0.01). Conclu-sion : Among the c-erbB-2 negative cases, the rate of lymph node metastasis in those with positive BCSG1and Survivin coexpression was significantlly higher than in those without expression of BCSG1 and Survivin.Detecting the expression of BCSG1, Survivin, and c-erbB-2 may be valuable for determining the biological be-haviors of breast cancer.