Abstract: Objective : To study the expression and serum levels of CD147 and MMP-2 protein in patients with col-orectal cancer, to investigate the correlation between CD147 and MMP-2, and to explore the relationship ofCD147 and MMP-2 with the invasion and metastasis of malignant tumor. Methods : Immunochemical stainingwas performed to detect the expression of CD147 and MMP-2 protein in colorectal cancer tissues, adjacenttissues, and normal controls. Semi-determination was performed by image analysis software. ELISA wasused to detect CD147 and MMP-2 in the peripheral blood of patients (44 cases of colorectal cancer) andhealthy controls (30 cases). Results : The expression of CD147 and MMP-2 in cancer tissues was significantlyhigher than in cancer tissues than in adjacent tissues and normal tissues, with no correlation with tumor typesand differentiation. But the expression of CD147 and MMP-2 was much higher in patients with metastasisthan in those without metastasis ( P <0.05). Serum levels of CD147 and MMP-2 were significantly higher in can-cer patients than in the normal controls ( P <0.05). The serum levels of CD147 and MMP-2 were associatedwith tumor differentiation and Dukes' stage. The serum level of CD147 was positively correlated with MMP-2in patients with colorectal cancer. Conclusion : The expression of CD147 is closely correlated with the malig-nant degree and metastasis in colorectal cancer, probably through activating and enhancing MMP-2 expres-sion.