Abstract: Objective: To investigate the effect of percutaneous vertebroplasty(PVP) used to treat bone metastasis of breast carcinoma. Methods: Data from 32 female patients with breast carcinoma and vertebral metastasis who received PVP were analyzed. Before PVP treatment, these patients were given chemotherapy or radiotherapy, and no obvious effect on the bone metastases was observed. Changes in pain intensity were assessed by NRS. Improvements in quality of life were evaluated by questionnaire EORTC QLQ-C30. The side effects were also observed. Results: The success rate of PVP was 100%. CT demonstrated that all of the defects from the vertebral metastases were fully filled by Polymethylmethacrylate(PMMA). The NRS was 6.69± 1.67 before PVP and was 3.09±1.84 at the 6th hour after the procedure (t=10.886, P=0.000). The score on the EORTC QLQ-C30 questionnaire was 60.60±3.57 before PVP and 34.61±4.31 at the 6th hour after PVP. The above data indicate that PVP decreased the patients' pain and improved their quality of life (t=43.924, P=0.000). No severe clinical complications were observed. Conclusion: PVP is a safe and effective treatment for breast carcinoma patients with vertebral metastasis.