Abstract: Objective: To analyze the prognostic factors of non-Hodgkin's Lymphoma (NHL) and to evaluate the prognosis of patients with different treatment. Methods: Data from 92 patients with NHL were retrospectively reviewed. Kaplan-Meier was employed to assess the survival rate and Cox regression model was adopted to analyze the prognostic factors. Results: The 2-year and 5-year disease-free survival (DFS) for all patients was 68% and 51%, respectively. The 5-year cancer specific survival (CSS) was 55%. Multivariate analysis by Cox regression showed that Ann Arbor stage, B symptom, LDH, IPI and age were independent prognostic factors. As for IPI, the 5-year CSS was 60% in patients with a score of 0~1, 62% in patients with a score of 2, 42% in patients with a score of 3, and 33% in patients with a score of 4~5. The 5-year survival in patients with stage I~II NHL was 19% in the surgery group, 72% in the chemotherapy group, and 68% in the group with surgery and chemotherapy. The 5-year survival in patients with stage III~IV NHL was 50% in the surgery group, 35% in the chemotherapy group, and 60% in the group with surgery and chemotherapy. Conclusion: The long-term survival of NHL patients is closely related to multiple factors. Surgery combined with chemotherapy can achieve better effects.