许建华, 郑正荣, 许双塔, 叶凯. 86例早期食管癌临床诊治探讨[J]. 中国肿瘤临床, 2008, 35(10): 547-550.
引用本文: 许建华, 郑正荣, 许双塔, 叶凯. 86例早期食管癌临床诊治探讨[J]. 中国肿瘤临床, 2008, 35(10): 547-550.
XU Jianhua, ZHENG Zhengrong, XU Shuangta, YE Kai. Clinical Analysis of 86 Cases of Early Esophageal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(10): 547-550.
Citation: XU Jianhua, ZHENG Zhengrong, XU Shuangta, YE Kai. Clinical Analysis of 86 Cases of Early Esophageal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(10): 547-550.

86例早期食管癌临床诊治探讨

Clinical Analysis of 86 Cases of Early Esophageal Carcinoma

  • 摘要: 目的: 探讨提高早期食管癌的诊断率和远期生存率的体会。 方法: 对福建医科大学附属第二医院自1998年1月至2004年12月手术治疗的86例早期食管癌进行回顾性分析。 结果: 本组病例部分早期食管癌症状大多轻微,自觉不适病程长短不一,X线检出率为84.9%(73/86),电子胃镜检查确诊率为100%(86/86)(其中尚有1例经过3次镜检获得病理诊断)。手术切除率为100%(86/86),并发症发生率为14.0%(12/86)。术后均未再行辅助治疗,定期随访,5年生存率为94.2%(81/86)。 结论: 早期食管癌的病程进展比较缓慢,症状轻微,呈非特异性,容易忽视,应高度重视早期食管癌的症状,采用内镜结合碘染色等检查方法多次检查(必要时采用多项检查方法和定期复查),结合临床症状综合分析,将有助于提高早期食管癌的诊断率。一些分子生物学指标被用于食管癌的实验室诊断,亦将有助于提高早期食管癌的诊断。早期食管癌的手术治疗远期疗效佳,手术治疗(食管次全切除并常规区域淋巴结清扫)是治疗早期食管癌的有效方法。术后复发与转移是早期食管癌患者术后死亡的主要原因。早期食管癌手术治疗不能完全达到治愈目的,且术后患者生存期较长,应定期密切随访,以便尽早对食管复发癌或转移癌进行有效的治疗,提高患者的生存质量和远期生存率。

     

    Abstract: Objective: To investigate the diagnosis rate and survival rate of early esophageal carcinoma. Methods: We retrospectively reviewed 86 cases of early esophageal carcinoma seen in our hospital between 1998 and 2004. Results: Seventy-three cases were identified by X-ray and all 86 cases were given a definitive diagnosis with esophagofiberoscopy.The diagnosis rate of electronic gastroscopy was 100% (86/86).The tumor resection rate was 100% (86/86) with a complication rate of 13.9% (12/86).No auxiliary treatment was administered.The 5-year survival rate was 94.2%. Conclusion: Symptoms of early esophageal carcinoma may be slight and non-specific and have a slow progression.Molecular biological targets can be used for laboratory diagnosis of esophageal cancer.Surgery consisting of inferior total excision and conventional region-al lymph node cleaning is the preferred method of treatment for early esophageal carcinoma.Early diagnosis is crucial for maintaining a high survival rate.Postoperative recurrence and metastasis are the major causes of death after surgery.Sur-gical removal may increase survival time, but surgery alone cannot completely cure these patients and regular follow-up is necessary for the improvement of patient survival.

     

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