Abstract: Objective : To evaluate the efficacy of treatment for hypopharyngeal squamous cell carcinoma and to ana-lyze the corresponding prognostic factors. Methods : We retrospectively reviewed the data from 151 patients with hypopharyngeal squamous cell carcinoma (2 stage Ⅰ cases, 17 stage Ⅱ cases, 28 stage Ⅲ cases, and 104 stage Ⅳ cases).Histologically, 63 were well differentiated, 50 were moderately differentiated, and 38 were poorly differentiated.Of the 151 patients, 70 were treated with radiotherapy, 24 were treated with surgery (group 1), 19 were treated with chemotherapy (group 2), and 38 were treated with combined therapy consisting of radiotherapy and surgery (group 3).Kaplan-Meier analysis was used to examine survival.Log-rank test was used to compare the differences in the efficacy of treatment among the three groups.Multi-variate analysis was performed using the Cox regression model. Results : The overall 3-year and 5-year sur-vival rates were 40.81% and 24.38%, respectively.The 5-year survival rate in patients with stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ hypopharyngeal squamous cell carcinoma was 100%, 56.47%, 27.68% and 16.78%, respectively.T-stage, cervical lymph node metastasis, clinical stage and treatment modality were associated with progno-sis.Multivariate analysis revealed that TNM stage and the response to primary treatment were independent prognostic factors. Conclusion : Hypopharyngeal squamous cell carcinoma is generally of advanced stage at the initial diagnosis and as such it has a high incidence of cervical lymph node metastasis, leading to a poor prognosis.Surgery combined with radiotherapy is currently the best treatment, but further research is needed to optimize scheduling of the combined therapy.