Abstract: Objective : To investigate the expression of Angiopoietin-2 (Ang-2), Tie-2 and CD34 in hepatoma tissues, para-cancer tissues, tissues of hepatic cirrhosis and normal tissues, to study the correlation of Ang-2 and tyro-sine kinase receptor Tie-2 with the angiogenesis in primary hepatic carcinoma (PHC), and to explore the role of Ang-2 and Tie-2 in the angiogenesis of PHC. Methods : Specimens from 32 PHC patients and 15 patients with hepatic cirrhosis and 10 samples of normal liver tissue were detected with S-P immunohistochemistry. Results : Ang-2, Tie-2 and CD34 were significantly up-regulated in tissues of PHC compared with tissues of hepatic cirrhosis and normal liver tissues.The expression of Ang-2, Tie-2 and CD34 was absent in normal liv-er tissues.The expression of Ang-2, Tie-2 and CD34 in tissues of liver carcinoma was higher than in tumor ad-jacent tissues.The expression of Ang-2, Tie-2 and CD34 in tissues of liver carcinoma was significantly higher than in hepatic cirrhosis and normal liver.There was a positive correlation between Ang-2/Tie-2 and MVD.The expression of Ang-2 and Tie-2 in tissues of PHC was correlated with MVD, histopathological grading and invasion of PHC. Conclusion : The expression of Ang-2 and Tie-2 in primary hepatic carcinoma was correlated with angiogenesis and MVD of hepatic carcinoma.Ang-2 can specifically bind with Tie-2.Ang-2 and Tie-2 may play a critical role in promoting tumor angiogenesis of PHC.