李小龙, 高明, 郑向前, 于洋. 甲状腺乳头状微小癌的临床生物学特性研究[J]. 中国肿瘤临床, 2008, 35(23): 1325-1327.
引用本文: 李小龙, 高明, 郑向前, 于洋. 甲状腺乳头状微小癌的临床生物学特性研究[J]. 中国肿瘤临床, 2008, 35(23): 1325-1327.
LI Xiao-long, GAO Ming, ZHENG Xiang-qian, YU Yang. Clinical and Biological Characteristics of Papillary Thyroid Microcarcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(23): 1325-1327.
Citation: LI Xiao-long, GAO Ming, ZHENG Xiang-qian, YU Yang. Clinical and Biological Characteristics of Papillary Thyroid Microcarcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(23): 1325-1327.

甲状腺乳头状微小癌的临床生物学特性研究

Clinical and Biological Characteristics of Papillary Thyroid Microcarcinoma

  • 摘要: 目的 :研究甲状腺乳头状微小癌的临床生物学特性,探讨更加合理的微小癌外科处理原则。 方法 :选取天津医科大学附属肿瘤医院自2003年1月至2006年12月间收治的具有完整病历记录的甲状腺乳头状癌383例,按国际最新甲状腺肿瘤的组织学分类标准分型,统计分析其中微小癌的发生率、性别比例、好发年龄、颈淋巴结转移程度、区域淋巴结转移规律等临床生物学特性。 结果 :所有病例中甲状腺乳头状微小癌110例,发生率为28.7%。微小癌可同时合并其他组织学变型,其中硬化型最常见,发生率为20.9%;侵袭转移能力较高的高细胞型占3.6%。微小癌在性别及年龄分布上与总体甲状腺乳头状癌相比无明显差异(P>0.05)。383例甲状腺乳头状癌颈淋巴结转移率为74.7%,而微小癌颈淋巴结转移率为20.0%,低于总体淋巴结转移率(P<0.05)。在所有转移性甲状腺乳头状微小癌中,90.9%的病例出现Ⅵ区淋巴结转移,仅2例为跨越Ⅵ区直接转移至其它区域。此外所有病例中远处转移(肺)1例,微小癌未见远处转移。 结论 :甲状腺乳头状微小癌较乳头状癌总体淋巴结转移率低,但亦可合并有高侵袭性组织学变型,可在早期发生颈淋巴结转移,因此不可全部按照Ⅰ期甲状腺癌处理。90.9%微小癌的淋巴结转移是以Ⅵ区为第一站。此区淋巴结阳性,具有指导术式选择的作用。

     

    Abstract: Objective : To investigate the clinical and biological features of papillary thyroid microcarcinoma. Methods : Data from 383 patients with papillary thyroid carcinoma seen in our hospital between January 2003 andDecember 2006 were retrospectively reviewed. WHO guidelines for papillary thyroid microcarcinoma were em-ployed. Results : Of these 383 patients, 110 (28.7%) cases were identified as microcarcinoma. Other histologi-cal variants were also observed in those cases classified as microcarcinoma. The rates of diffuse sclerosingvariant and tall cell variant were 20.9% and 3.6%, respectively. No significant difference was found in age orgender between microcarinoma and conventional papillary thyroid carcinoma (P>0.05). The rate of cervicallymph node metastasis in patients with microcarcinoma was 20.0%, lower than that in patients with conven-tional papillary thyroid carcinoma (P<0.05). The rate of metastasis to section VI was 90.9%. No distant metas-tasis was found in patients with microcarcinoma. Conclusion : Although the rate of cervical lymph node metas-tasis from papillary thyroid microcarcinoma is low, careful monitoring should be upheld because aggressivevariants exist. All cases of microcarcinoma cannot be considered and treated as stage I carcinoma. Individual-ization is critical in the treatment of papillary thyroid microcarcinoma.

     

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