Abstract: Objective : Lung cancer is one of the most common solid tumors that metastasizes to bone. The aim ofthis study was to assess prognostic factors of patients with bone metastasis from lung cancer. Methods : Wefollowed up 127 patients with bone metastases from lung cancer seen in our hospital during October 1997and January 2007. There were 84 males and 43 females with an average age of 61.2 years. Plain radio-graphs, CT, MRI and bone scintigraphy were used for detection of bone metastases. Based on pathologicstudy, tumors were histologically identified as adenocarcinoma in 80 patients (63.0%), squamous cell carcino-ma in 17 patients (13.4%), large cell carcinoma in 9 patients (7.1%), and small cell carcinoma in 21 patients(16.5%). We used Kaplan-Meier survival curve and Cox comparative hazards model to analyze prognostic fac-tors. Several predictors of survival have been identified. Results : The 6-month and 1- and 2-year cumulativesurvival rates after bone metastasis from lung cancer were 72.4%, 25.8%, and 8%, respectively. The mediansurvival time of these patients was 10.6 months, and the median survival time after the diagnosis of bonemetastasis was 6.7 months. Univariate analysis showed that the significant prognostic factors for survival oflung cancer patients with bone metastasis included patients'survival state, tumor subtype, the number ofmetastatic foci, bone destruction, visceral metastases, the interval between the diagnosis of lung cancer andbone metastasis, presence of skeletal complications (pathologic fracture or spinal cord compression). Multi-variate analysis showed that the significant prognostic factors included patients'survival state, tumor sub-type, the number of metastasis foci (isolated or multiple), visceral metastases, and interval between the diag-nosis of lung cancer and bone metastasis. Conclusion : The prognostic factors for survival are useful for deter-mining the optimal surgical method, and they are valuable for improving the survival of lung cancer patientswith bone metastases.