Abstract: Objective: To investigate the quality of life of patients with advanced prostate cancer after treatmentwith intermittent androgen blockade(IAB). Methods: A total of 51 patients with advanced prostate cancer treated with IABunderwent the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) andthe QLQ-prostate specific 25-item module (PR25). The assessment was made 3 times: once before treatment, once 6months after treatment and once 12 months after treatment. Results: In spite of the increased financial burden, IAB bene-fited patients. At 6 and 12 months after treatment, improvement was observed in pain relief, urinary symptoms and globalhealth (P<0.01). Six months after treatment, patients treated with IAB presented with decreased physical, role, emotionaland social functions compared to those same patients before treatment(P<0.01). At that time patients also had symptoms re-lated to the treatment itself including flushed skin, breast pain and decreased libido. The above functions were improvedand the treatment-related symptoms were relieved by the 12th month after treatment. Conclusion: IAB can effectively im-prove the quality of life for patients with advanced prostate cancer. It temporarily impairs physical and psychological func-tions, but these functions can be fully recovered within 12 months of treatment.