Abstract: Objective: : To study the effect of limb-salvage surgery for malignant tumors in limbs. Methods : Data from102 patients with malignant limb tumors treated between March 1999 and September 2007 were reviewedand analyzed. Results : Seventy-six patients were treated with 4-6 cycles of neoadjuvant chemotherapy, andthe other 26 cases received no chemotherapy or were treated with postoperative chemotherapy alone. Of the76 patients treated with neoadjuvant chemotherapy, 12 cases did not relapse in four years, 10 cases did notrelapse in five years, and 41 cases did not relapse in six years. Of all 102 cases, 40 were treated with radicalexcision, of which 13 cases did not relapse in five years, 9 cases did not relapse in six years, and 3 cases didnot relapse in eight years. Conclusion : Malignant tumors in limbs should be treated with combination therapybased on stage, classification, biological characteristics, and sensitivity to chemotherapy. Surgery andchemotherapy together are essential for achieving a satisfactory survival rate.