Abstract: Objective: : To investigate the relationship between the serum vascular endothelial growth factor-C(VEGF-C) level and the clinicopathological features in patients with non-small cell lung cancer (NSCLC). Methods : Serum level of VEGF-C in 20 healthy normal controls, 30 cases of pneumonia, and 60 cases ofNSCLC were detected by ELISA. The relationship between VEGF-C expression and the clinical features wasanalyzed. Results : Serum VEGF-C in the NSCLC patients was significantly higher than in the healthy controls(P<0.01) and patients with pneumonia (P<0.05). NSCLC patients with lymph node metastasis had a higherVEGF-C level than those without lymph node metastasis (P<0.05). Stage Ⅲ and stage Ⅳ NSCLC patientshad a higher VEGF-C level than stage Ⅰ and stage Ⅱ NSCLC patients (P<0.01). Serum VEGF-C level had anegative correlation with the survival time of NSCLC patients (P<0.05). Conclusion : Serum VEGF-C level inNSCLC patients is correlated with disease progression and survival time. Serum VEGF-C level can thereforeserve as a prognostic marker of NSCLC.