Abstract:
Intensity modulated radiotherapy (IMRT) has increased the local-regional control rate and decreased thecomplications of radiotherapy for nasopharyngeal cancer(NPC). CT and MRI fusion is currently the optimal modality to de-lineate the extent of the primary spread of this disease. The key factor affecting neck node delineation is how to translateanatomic node regions into the CT boundaries. The consensus guidelines that narrowed the gap among different cancercenters are recommended for delineating the boundary of the cervical lymph node regions. The definition of the gross tu-mor volume (GTV) of NPC is clear and is almost the same among the main cancer centers in their IMRT planning proto-cols. The actual dose to the GTV is close to or more than 80 Gy. The main differences among those cancer centers lay inthe definition of the CTV, its dose prescription scheme, and the dose to the high cervical region. Their long-term follow-up results suggested that, beside the 5 mm-10 mm margins, the immediate high risk structures (including the entire na-sopharyngeal cavity, retropharyngeal space, clivus, base of the skull, pterygoid plates and muscles, parapharyngeal space,the sphenoid and partial ethmoid sinuses, the posterior third of the maxillary sinuses and the nasal cavity) should also beincluded in the delineation and should be treated with more than 60 Gy. Bilateral node level Ⅰb, Ⅱ and Ⅴa should beranked as high risk regions and differentially treated with no less than 60 Gy.