Abstract: In recent years, the incidence of pancreatic cancer has been increasing. With a high invasive ability andlow rate of early diagnosis and surgical resection, pancreatic cancer has a poor prognosis. Combined therapyconsisting of radiotherapy, chemotherapy and palliative surgery is the primary management for advanced pancreatic cancer. The purpose of treatment for advanced pancreatic cancer is to improve the quality of life andprolong survival. Gemcitabine is the standard chemotherapy at present, and Gemcitabine-based combinations have shown a favorable or potentially favorable impact on survival. Development of new drugs will bringhope to patients with advanced pancreatic cancer.