Abstract: Objective : To investigate the relationship between lymphatic vessel invasion (LVI) and other correlatedpathologic factors in adenocarcinoma of the esophago-gastric junction. Methods : A total of 156 patients withesophago-gastric junction adenocarcinoma who underwent radical surgical resection were recruited and divided into two groups: the LVI-positive group and the LVI-negative group. The incidence of LVI was evaluatedwith the χ ² test among patients with different N stages, T stages, morphological and histological type, tumorsize and the number of involved lymph nodes. The difference in tumor differentiation between the LVI (+)group and the LVI (-) group was compared by nonparametric Mann-Whitney U test. The tumor size and thenumber of lymph nodes with metastases LN(+) were estimated between the LVI (+) group and the LVI (-)group using the independent samples t test. Results : (1) The incidence of LN (+) was 61.2% in the LVI (+)group and 95.5% in the LVI (-) group, with a significant difference. The incidence of LVI was 13.3% in patientswith involved lymph nodes and 67.5% in patients without involved lymph nodes, with a significant difference.(2) All cases of T₁ stage were LVI (-). No significant difference was found in the incidence of LVI betweenstages T₂ and T₃. Most T₄ stage cases were LVI (+). (3) A statistical significance was found in the incidence ofLVI between well-differentiated cases and poorly-differentiated cases. The poorly-differentiated cases weremostly LVI (+). (4) The tumor size was 6.09+3.40 cm in the LVI (+) group and 9.75+7.82 in the LVI (-) group.The number of involved lymph nodes was 4.34+2.07 in the LVI (+) group and 2.63+2.00 in the LVI (-) group. Conclusion : There is a significant correlation between LVI and N stage, T stage, the morphological and histological type, the tumor differentiation, tumor size and the number of involved lymph nodes.