Abstract: Objective : Radical resection is the main treatment for gastric cancer (GC). However, surgery is not theonly parameter which may affect the prognosis for GC. This study was designed to investigate the prognosticfactors related to the long-term survival following radical gastrectomy. Methods : A total of 320 patients withgastric cancer who underwent radical gastrectomy in our hospital from 1998 to 2005 were retrospectively analyzed. There were 98 (30.6%) D₁ redical resections, 205 (64.1%) D₂ resections, 13 (4.1%) D₃ resections and 4(1.3%) D₄ resections. There were 155 patients who received intra-peritoneal chemotherapy with activated carbon plus MMC. All patients had received adjuvant chemotherapy with Oxaliplatin, Tegafur, and Leucovorin, except for early GC cases and those who couldn’ t tolerate chemotherapy. Kaplan-Meier method was applied toanalyze survival rates, and Log-rank test was performed to assess statistical significance among thesegroups. Results : There were 14 cases with post-operative complications and 25 cases with recurrence and/ormetastases. There were only 6 cases with recurrence and/or metastases in those who had received intraperitoneal chemotherapy. Pattern of resection (P<0.001), TNM stage (P<0.001), extent of lymph-node metastasis(P<0.001), multiple-organ resection (P<0.001) and intra-peritoneal chemotherapy (P<0.05) were related withpost-operative survival. Gender, age, clinical symptoms, extent of lymphoadectomy and pathological typewere not correlated with prognosis. Conclusion : Pattern of resection, TNM stage, extent of lymph-node metastasis, multiple-organ resection and intra-peritoneal chemotherapy were independent prognostic factors for gastric cancer patients following radical gastrectomy. Early detection and management, as well as radical surgerycombined with multidisciplinary therapeutic strategy may play important roles in improving post-operativelong-term survival.