Abstract: Breast cancer is the most common cancer seen in women, and its metastasis is the leading cause of deathin breast cancer patients. Breast cancer metastasis model is an important tool to identify breast cancer metastasis-relatedgenes, to investigate molecular mechanisms of metastasis and to test therapeutic efficacy of anti-metastasis medicine.Breast cancer metastasis models include spontaneously metastasis model, induced metastasis model, transgenic metastasismodel and transplantable metastasis model. Transplantable metastasis model is widely used because of its advantages suchas rapid time course for model maturity and consistent biology of metastasis. Transplantable metastasis models of breastcancer include experimental metastasis model and spontaneous metastasis model according to different ways in which tu-mor cells are transplanted to the recipient animals. Experimental metastasis is formed by retention and proliferation of tu-mor cells which are injected directly into vascular system. This model can develop metastasis with high incidence in ashort experimental period, but it bypasses the process of carcinogenesis in situ and invasion process of tumor cells fromprimary site to vascular system. Spontaneous metastasis model is built by inoculating tumor cells or tissues into subcuta-neous, muscular, and mammary fat pad, which results in the formation of a local tumor that will eventually give rise tometastases at distant organs. This model being an important tool for research of the metastatic mechanism of breast cancer,involves the entire process of metastasis of tumor cells from primary site to distant organs. Significant progress has beenmade in detecting metastasis with the development of in vivo imaging, by which not only micrometastasis can be detectedearly, but also the metastatic status in recipient animal can be observed dynamically. We review the methods of establish-ing ransplantable breast cancer metastasis models, their classification, and application in the research of molecularmechanisms of breast cancer metastasis and in the experiment on anti-metastasis therapy.