祝淑钗, 沈文斌, 李娟, 苏景伟, 王玉祥, 李任. 胸段食管癌临床分期与病理TNM分期对比研究[J]. 中国肿瘤临床, 2008, 35(5): 256-258,268.
引用本文: 祝淑钗, 沈文斌, 李娟, 苏景伟, 王玉祥, 李任. 胸段食管癌临床分期与病理TNM分期对比研究[J]. 中国肿瘤临床, 2008, 35(5): 256-258,268.
ZHU Shu-chai, SHEN Wen-bin, LI Juan, SU Jing-wei, WANG Yu-xiang, LI Ren. Comparison of Pathological TNM Staging and Clinical Staging for Patients with Thoracic Esophageal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(5): 256-258,268.
Citation: ZHU Shu-chai, SHEN Wen-bin, LI Juan, SU Jing-wei, WANG Yu-xiang, LI Ren. Comparison of Pathological TNM Staging and Clinical Staging for Patients with Thoracic Esophageal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(5): 256-258,268.

胸段食管癌临床分期与病理TNM分期对比研究

Comparison of Pathological TNM Staging and Clinical Staging for Patients with Thoracic Esophageal Carcinoma

  • 摘要: 目的: 探讨胸段食管癌临床分期的准确性并结合病理TNM分期进行对比分析。 方法: 58例可切除胸段食管癌,术前行钡餐造影、胸部CT扫描和腹部超声波检查,根治术后病理均为鳞状细胞癌。病理TNM分期:Ⅱa期28例占48.3%,Ⅱb期2例占3.4%,Ⅲ期27例占46.6%,Ⅳ期1例占1.7%。术前临床分期:Ⅱ期27例占46.6%,Ⅲ期28例占48.3%,Ⅳ期3例占5.2%。采用方差分析和相关性检验统计两种分期的相关性和符合性。 结果: 术后病理T分期与术前临床T分期的相关性不明显r=0.233,P=0.079;而术后病理N分期与术前临床N分期具有显著性相关r=0.285,P=0.030;病理TNM和临床TNM分期有显著性相关r=0.289,P=0.028。术后病理淋巴结转移者30例占51.7%,术前CT片淋巴结肿大者33例占56.9%,二者具有显著性相关r=0.388,P=0.003。病理TNM分期和临床TNM分期均呈现分期越晚转移淋巴结个数越多,同样钡餐造影的病变长度也随期别越晚,病变长度越长,且有统计学意义。临床T分期与CT片显示的肿大淋巴结个数和术后病理淋巴结转移个数均具有显著性相关r=0.289,P=0.028和r=0.298,P=0.023,然而病理T分期与淋巴结转移并未显示相关性。 结论: 两种分期系统有一定相关性和符合率,但仍存在较大差距,主要是病变局部T分期在早期病例的符合率较差,内窥镜超声介入可能会有所帮助。

     

    Abstract: Objective: To explore the accuracy of clinical staging for patients with thoracic esophageal carcinoma,and compared it to the pathological TNM staging. Methods: A total of 58 patients with resectable thoracic esophagealcarcinoma underwent preoperative esophagogram, chest CT scanning and ultrasonography, and then received complete re-section. All of them were diagnosed with squamous cell carcinoma. Pathological TNM staging showed that there were 28Ⅱa cases(48.3%), 2 Ⅱb cases(3.4%), 27 Ⅲ cases(46.6%), and 1 Ⅳ cases(1.7%). Clinical TNM staging showed that therewere 27 Ⅱ cases (46.6%), 28 Ⅲ cases (48.3%), and 3 Ⅳ cases(5.2%). Results: There was a significant correlation be-tween pathological N stage and clinical N stage (r=0.285, P=0.030). A correlation was also found between pathologicalTNM and clinical TNM staging (r=0.289, P=0.028). No correlation was found between pathological T stage and clinical Tstage. There were 30 patients (51.7%) with pathologically proved lymph node metastasis and 33 patients (56.9%) with en-largement of lymph nodes in chest CT scanning. The number of enlarged lymph nodes and the length of local tumor wereincreased as the stages advanced. We observed a clearly correlation between the clinical T stage and the number of en-larged lymph nodes in CT, and the number of pathological positive lymph nodes. Conclusion: There are definite correla-tion and accordance between the two systems of staging but some differences exist in the T stages for patients at earlystage. Endoscopic ultrasonography may be useful in reducing the disparity.

     

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