Abstract: Tumor dormancy, a complex and still poorly understood phenomenon observed both in experimentalmodels and in patients, has been defined by the long-term persistence of occult cancer cells during tumor progression.Recurrence and metastasis may occur because of this small population of tumor cells. Sustained angiogenesis is consideredessential in triggering invasive tumor growth. Here we discuss the correlation between angiogenesis and tumor dormancy,the establishment of tumor dormancy models and new biomarkers for detecting microscopic tumors before or during the an-giogenic switch. The imaging techniques and the different strategies for isolation of both angiogenic and non-angiogenictumor cell populations are also summarized. To eradicate dormant disease, it is imperative to understand the role of angio-genesis in tumor dormancy.