乳腺浸润性导管癌中OGF OGFR的表达研究

胡建功; 金小萍; 谢朝辉; 邢恩鸿; 张祥宏

乳腺浸润性导管癌中OGF OGFR的表达研究

The Expression of OGF and OGFR in Invasive Ductal Carcinoma of the Breast

摘要

摘要: 目的: 探讨乳腺浸润性导管癌中OGF、OGFR的表达意义。 方法: 采用免疫组化SP法检测18例正常乳腺、12例乳腺腺病、8例乳腺异型上皮增生、21例浸润性导管癌组织中OGF、OGFR的表达。 结果: 在正常乳腺组、乳腺腺病组、乳腺异型上皮增生组、浸润性导管癌组中OGF表达率分别为55.43%、43.48%、34.50%、13.29%,各组间差异有统计学意义(P<0.01);OGFR表达率分别为68.80%、44.22%、40.00%、25.52%,各组间差异有统计学意义(P<0.01)。 结论: 乳腺组织中可能存在着OGF-OGFR的相互作用;OGF、OGFR的表达减少,减弱了OGF-OGFR的相互作用,可能促进了乳腺癌的发生、发展。增加OGF、OGFR的表达,促进两者的相互作用,可能对乳腺癌的治疗起着重要作用。

Abstract: Objective: To investigate the expression of OGF and OGFR in invasive ductal carcinoma of the breast. Methods: We used immunohistochemistry to detect the expression of OGF and OGFR in 18 samples of normal breasttissue, 12 samples of adenosis, 8 samples of atypical ductal hyperplasia and 21 samples of invasive ductal carcinoma ofthe breast. Results: The expression rates of OGF in these four kinds of tissues were 55.43%, 43.48%, 34.50%, and13.29%, respectively (P<0.001). The expression rates of OGFR in these four kinds of tissues were 68.80%, 44.22%,40.00%, and 25.52%, respectively (P<0.001). Conclusion: There may exist OGFOGFR interaction in the breast tissue.The decrease in the expression of OGF and OGFR may reduce the function of the OGFOGFR axis in maintaining cellproliferation and may contribute to the occurrence and development of breast carcinoma. To increase the expression ofOGF and OGFR, enhancing OGFOGFR interaction could be a useful treatment for breast tumor progression.

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