Abstract: Objective : To evaluate the clinical safety and efficacy of HIFU treatment of hepatic metastases from colorectal cancer. Methods : 31 tumor lesions totally in 18 patients with hepatic metastases from colorectal cancer were treated with HIFU therapy. The vital signs, main organs functions, examinations of CT or MRI, complications and tumor outcome were all observed. Results : Vital signs of all the patients were steady. The functions of liver and kidney were normal. The average of follow -up was 16.1 months (6-38 months). 2 cases lost their follow-up. 13 cases are still alive, and 12-, 18-month survival rates were 83.3%, 66.7% respectively and the median survival time was 16 months. In 25 tumor lesions, the decreasing rate of 17 cases exceed 50%. 5 cases had new metastatic lesions in 18 casese, 8 cases appeared skin injury with ! de-gree. Conclusions : HIFU treatment is safe and effective in therapy of the hepatic metastases from colorectal cancer.