张灿斌, 徐中一, 张克. Ⅰ期细支气管肺泡癌和腺癌的临床对比分析[J]. 中国肿瘤临床, 2004, 31(1): 33-35.
引用本文: 张灿斌, 徐中一, 张克. Ⅰ期细支气管肺泡癌和腺癌的临床对比分析[J]. 中国肿瘤临床, 2004, 31(1): 33-35.
Zhang Can bin, Xu Zhong yi, Zhang Ke. Clinical Analysis in Patients with Stage I Bronchioloalveolar Carcinoma and Adenocarcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2004, 31(1): 33-35.
Citation: Zhang Can bin, Xu Zhong yi, Zhang Ke. Clinical Analysis in Patients with Stage I Bronchioloalveolar Carcinoma and Adenocarcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2004, 31(1): 33-35.

Ⅰ期细支气管肺泡癌和腺癌的临床对比分析

Clinical Analysis in Patients with Stage I Bronchioloalveolar Carcinoma and Adenocarcinoma

  • 摘要: 目的:研究临床Ⅰ期细支气管肺泡癌和腺癌的临床特点、手术方法、肿瘤复发部位和预后。方法:将1982~1998年间手术切除的76例Ⅰ期细支气管肺泡癌和腺癌患者分成两组,并且进行长期随访,比较两组患者的发病特点、手术方式、肿瘤发生部位、术后复发部位、手术方式和预后的关系,细支气管肺泡癌随访7.3年,肺腺癌随访6.1年。结果:细支气管肺泡癌22例,女性13例(59%),无吸烟史者8例(36%);腺癌54例,女性25例(46%),无吸烟史者12例(20%)(P<0.05);术后细支气管肺泡癌胸腔内复发13例(87%),腺癌术后复发46例,胸腔内复发25例(61%),胸腔外转移22例(54%),其中骨转移18例(20%),脑转移5例(12%),肝转移6例(15%)。细支气管肺泡癌术后5年成活率为91%,腺癌为63%(P=0.02)。结论:Ⅰ期细支气管肺泡癌女性多于男性,与吸烟无明显相关性,术后复发多发生于胸腔内,肺叶切除术是常用的治疗方法。腺癌术后胸内和胸外复发基本相等,细支气管肺泡癌预后优于腺癌。

     

    Abstract: Objective : to compare the patient characteristics and surgical intervention. The pattern of recurrent carcinoma and prognosis in patients with stage I Bronchioloalveolar carcinoma and adenocarcioma of the lung. Methods : Seventy-six patients with stage I bronchioloalveolar carcinoma and adenocarcinoma resected between 1982 and 1998 were divided into 2 groups, and were taken follow-up for a long time. We compare the clinical characteristics, sites of carcinoma, surgical methods, sites of recurrent disease and survival time after operation. The median follow-up for patients with bronchioloalveolar carcinoma and adenocarcinoma was 7.2 years and 6.9 years respectively. Results : Twenty-two patients had bronchioloalveolar carcinoma and 54 patients had adenocarcinoma. Thirteen of the twenty-two patients (59%) with bronchioloalveolar carcinoma and twenty-five of the fifty-four (46%) patients with adenocarcinoma were women. Eight of the twen-ty-two patients (36%) with bronchioloalveolar carcinoma had never smoked as compared with 12 cases of 54 (20%) in the adenocarcinoma group. Thirteen of the fifteen (87%) patients with recur-rent bronchioloalveolar carcinoma were within the lung parenchyma. In contrast, extrathoracic metastases were common in the patients(twenty-two of the forty-six patients, 54%) with adenocar-cinoma, of these patients with recurrent adenocarcinoma20% has metastases to bone, 12%to brain, 15%to liver, Patients with bronchioloalveolar carcinoma lived longer (5 year survival 91%) than patients with adenocarcinoma (5 years survival 63%) after resection of their stage 1 disease(P=0.02). Conclusion : Stage I bronchioloalveolar carcinoma is more likely to occure in worman. No obvious relation is found with smoking. The greater tendency for intrapulmonary metastases is the most commonly and lobectomy is performed commonly in our patients with bronchioloalveolar carcinoma. The prognosis with this type is better than that adenocarcinoma type.

     

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