Abstract: Objective : Paget's disease is an uncommon breast malignancy and often misdi-agnosed. If the patient is treated in early stage, the prognosis is satisfied. Our study analyzed the cfinical characteristic of the disease and the factors influencing the prognosis. Meth-ods : 45 pa-bents with Paget's disease who were admitted our hospital were analyzed retrospectively. Results :The most common symptoms of the disease were erosion and bleeding like eczematoid change atnipple/areola. Of the 40 patients with eczematoid change, 11 patients had verified paget's diseasewith a palpable mass on physical examination, and 29 patients had verified paget's disease withnonpalpable mass. Five patients only manifested a mass with no eczematoid change. Thirteen pa-bents had lateral axillary lymphadenopathy. In this study, 25 cuses were treated by radical mas-tectomy and 20 cuses were treated by modified radical mastectomy. Five and ten-year survival ratesfor the patients with nonpalpable mass and for those with palpable mass were 95.5%, 78.6%, and53.8%, 36.4% respectively. The former were significantly better than latter P value <0.01 and <0.05 respectively). Five and ten-year survival rates for the patients without underlying carcinoma (DCIS/IDC) and for the patients with underlying careinoma were 100%, 88.9%respectively. The former were significantly better than latter (P value <0.05).survival rates for the patients with lymph nodes negative and for the patientsand 69.6%, 43.8%Five and ten-yearwith lymph nodes positive were 92.0%, 76.5% and 50.0%, 25.0% respectively. The former were also significantly better than latter (P value <0.05). Conclusion : The treatment in early stage is very important and influences the prognosis directly for Paget's disease of breast. The survival of the patients withnonpalbable mass, without underlying carcinoma and without lymphadeno pathy were significantly better than the patients with palpable mass, with underlying carcinoma and with lymphadenopathy respectively. There was significant statistic difference between each two groups.