Abstract: Objective : To explore how to pull up resected rate of peri-ampullar tumor anddecrease complication of pancreatoduodenectomy-pancreatic fistula. Meth-ods : 126 patients under-went pancreatoduodenectomy were restrospectively reviewed from March 1995 to December 2000in our hospital. Results : Improvement of pancreatoduodenectomy increased the resected rate andsurvival rate, but the complication was not increased. Survival rato of 1,3 years were 71.4%,48.6% respectively.Incidence rate of pancreatic fistula after pancreaticojejunostomy with end-to-end was 4.8%,and there was no incidence of pancreatic fistula when the anastomotic stoma ofpancreaticojejunostomy with end-to-side was covered by pedunculated greater omentum. Conclusion : Pancreatoduodenectory with radical resection of portal vein could be performed safely. Pan- creaticojejunostomy (end-to-side) with the anastomotic stoma covered with greater omentum couldavoid effectively incidence of pancreatic fistula.