Abstract: Objective : To analyze the change of ratio of apoptosis of cell of A M L which had treat with chemotherapy and α interferon as well as this kind relation between changing and complete remission (CR). Methods : Ratio of apoptosis and CR of 22 cases which had treat with chemotherapy and a interferon (group 1) and 23 cases which had treat only with chemotherapy (group 2) are analyzed Results : Ratio of apoptosis in group 1: before treatment 0.0487±0.0430, after first course 0.2522±0.0849,cumulate one after second course 0.3253 ±0.0918 ; ratio of apoptosis in group 2: before treatment 0.0491 ±0.0440, after first course 0.1845±0.0812, cumulate one after second course 0.2580±0.1127. ratio of apoptosis in first course (t=2.733, P=0.009) and second course (t=2.188, P=0.0350) had significant difference between group 1 and group 2. CR in group 1: had 19 cases (86%)after first course, had cumulate 20 ones (90%) after second course. C R rate in first course (χ₂=7.515, P =0.006) and cumulate CR rate in second course (χ₂=5.494, P=0.019) had significant difference between group 1 and group 2. Conclusion : Ratio of apoptosis and CR rate had an increase after treatment with chemotherapy and a interferon.