Abstract: Objective :To investigate the clinical pathology of endometrial carcinoma in pre-menopausal patients. Methods : The clinical pathology and prognosis of 158 cases with endometrialcarinoma were analyzed retrospectively. Of them, 49 were in premenopausal group(stud y group) and 109in postmenopausal group (control group). Results : When the premenopausal group was compared withthe postmenopausal group, the rate of cases with familial cancer was higher(22%&9.92%), the specialtumor type was more infrequent (2.04%&12.84%), the tumor grade was lower (G, were 71.43%&43.12% respectively), the deep myometrial invasion was less (18.37%&38.53%), the five years sur-vivial rate was higher (91.11%&73.47%). In the all aspects mentioned above, P<0.05 respectively.Moreover, in premenopausal group, cases combined with uterine myoma were more common, and therate of misdiagnosis was higher (P<0.05). Conclusion : The clinical and pathological characteristics ofendometrial carcinoma might be responsible for the better prognosis of premenopausal patients tom-pared with menopausal. The premenopausal women with abnormal uterine bleeding might suffer fromendometrial carcinoma, and should undergo additional work-ups to clarify the diagnosis earlier.