Abstract: Objective : To study the pathological characteristics of brease-duct disease with nippledischarge under breast duct endoscope and improve diagnostic accuracy. Methods : 354 patients withnipple discharge were examined by fiberoptic duct endoscope (FVS-3000M), to investigate concernedduct with its branch and define location and extent of intraductal leisions, core biopsy can be appliedin suspicious leisions. Results : In bloody nipple discharge, papilloma was 72.3% ,duct cancer was5.2%, mammary duct ectasia and galactophoritis was 22.5%,5 patient is normal. Conclusion : Fiberopticduct endoscopy can locate accurate site and pathogeny of nipple discharge, to allow the improving indiagnosis of early breast cancer.