Abstract: Objective : This study was undertaken to identify prognostic factors through a retrospective analysis of clinicopathologic characteristics of 723 colon cancer patients. Methods : A total of 723 patients with colon cancer, which were treated surgically during a period of 10 years,were studied by univariate and multivariate analysis. Results : R0, R1 and R2 operations were carried out in 550 patients (76.07%), 25 patients (3.46%) and 148 patients (20.47%), respectively. The operation mortality was 0.55% , 278 patients were dead within 108 months postoperatively since recurrence or metastases of the tumor. Liver and lung metastases were occurred in 16 and 7 patients, respectively. The mean survival time for all patients was 80.19±1.87 months and the 3, 5 and 10 year survival rates after radical operations were 84.69%、76.07%、67.48%, respectively. Kaplan-Meier estimates showed that the predictors of survival were type of operations, radical resection, blood transfusion, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, distance metastases, liver, lung metastases and TNM stage. Using multivariate analysis only radical resection, depth of tumor invasion, lymphatic invasion, distance metastases and TNM stage were associated with outcome. Conclusions : Multivariate analysis revealed the follow prognostic factors: radical resection, depth of tumor invasion, lymphatic invasion, distance metastases and TNM stage.