Abstract: Objective : To detect the expression of focal adhesion kinase (FAK) in colorectal carcinoma and adjacent normal tissues and investigate the significance of FAK in tumorigenesis and progression of colorectal carcinoma. Methods : The expression of FAK m RNA in 30 samples of colorectal carcinoma and adjacent normal tissues was examined using fluorescence quantitative RT -NCR(FQ-RT-PCR). Results : The FAK m RNA levels in colorectal carcinoma tissues were significantly higher than those in adjacent normal tissues (P=0.011). The carcinoma with lymph node metastasis had more FAK mRNA expression than those in adjacent normal tissues (P=0.011). The carcinoma with lymph node metastsis had more FAK mRNA expression than those without lymph node metastasis (P=0.021) and the deeper extent of infiltrating, the higher FAK m RNA expression (P=0.038). Conclusion: FAK is related to the infiltrating and metastasis of colorectal carcinoma. The level of FAK expression might be a valuable marker for the carcinogenese and progression of the carcinoma.