Abstract: Objective : The expression of FHIT, PTEN were immunohistochemically detected to investigate the differences among them and affects of these oncogens on the prognosis in esophageal carcioma.and to provide a theoretical basis for clinical treatment and predicting prognosis. Methods :Paraffin -embedded tissue blocks of 160 cases of esophageal carcinoma were obtained from the Forth Hospital of Hebei Medical University. the immunological reagents employed included antibodyies of FHIT, PTEN. Follow-up data for 40 cases of ESC and 94 cases of ESCC could be used for analysis. Results : The positive rate of FHIT, PTEN in ESC and ESCC has significant differences. The expression of FHIT, PTEN and the correlation between prognosis could be found in the ESC. The expression of FHIT and PTEN in the EScc were low.Its biological behavior had high malignant degree and five-year survival rates were low. But in the ESC the expression was higher and the malignant degree was lower,and five-year survival rates had improved much. The expression of these oncogenes was related to the histological types and differentional degree. Conclusion : It is valuable for clinical treatment and judging prognosis to detect the expression of FHIT and PTEN in esoghageal carcinoma.