Abstract: Objective : Yasculogenic mimicry was studied in malignant melanoma by constructing tumor cell tridimension culture system, animal experiment and trans-electron microscope. Methods :To construct tumor cell tri-dimension culture system and animal experiment malignant melanoma B16 model, observe the morphologic diversification structure and blood supplyment of malignant melanoma where vasculogenic mimicry was investigated. Those tumors which exist vasculogenic mimicry was observed by electron microscope. Results : Animal experiment and electron microscope proved that vasculogenic mimicry exists in malignant melanoma. Tri-dimension culture model of malignant melanoma cell line also testified the tumor cells self-metamorphose and vasculorized trend. conclusion: Yasculogenic mimicry exists in malignant melanoma. The tumor cell can obtain oxygen and nutriment through this structure.