Abstract: Objective : By THPDDP -5-Fuscheme, the paper tries to explore before the curative effect of one -cycle induction chemotherapy the radiotherapy in Ⅲ Ⅳ a nasopharyngeal carcinoma (NPC). Methods : From Ded • 1996 to June • 1998, 82 patients with locally Ⅲ Ⅳa NPC were accepted by Nan Hua Hospital. The hospital divided them into two groups to treat. One was Group A (THP .DDP•5-FU combined with radiotherapy) with 42 patients, the other was Group B (radio therapy alone)with 40 patients. So patients in Group A were treated by T H P 50mg/m² .day; DDP 80mg/m² -day and 5-FU 200mg /m²/ day for five consecutive days. Two days later after the induction chemotherapy was finished. NPC was began. Results : When radiotherapy was completed, the control rates of the tumor of nasopharyx of Group A and Group B were 88% and 67.5% (P<0.05) respectively. The tumor of neck of Group A and Group B were 87% and 40.4% (P<0.01) respectively; The complete remission CR of Group A and Group B were 90.4%, 52.5% ( P<0.01 respectively). The overall 5-year survival of Group A and Group B were 50.0%(21/42) and 27.5%(11/40) (P<0.05) respectively. Conclusion : This study demonstrates that THP•DDP•5-FU induction chemotherapy 1 cycles followed by radiotherapy can improve the latest curative effect and raise the rate of 5-year survival¹ .