Abstract: Objective : To study the therapeutic efficacy and toxic side effects of radiotherapy with synchronous chemotherapy on stage T₂N₂M₀ nasopharyngeal carcinoma, thus to investigate its feasibility. Methods : 70 cases of stage T₂N₂M₀ nasopharyngeal carcinoma were randomly assigned to group A which was subjected to combined radiotherapy and chemotherapy and group B which was subjected to radiotherapy simply. The methods, times and dose schedule of radiotherapy were similar in the two groups. Patients in the combined treatment group were subjected to chemotherapy of cis -dichlorodi-amine platinum(DDP) and 5-Fliorouracil (5-FU) at the 1^st , 4^th and 7t h week after radiotherapy. All the patients underwent the treatment as planned. Results : W h e n the dose of radiotherapy was 40GY, the CR+PR rate of nasopharyngeal foci and cervical limph nodes in group A were 74.29% (26/35)and 94.29% (33/35) respectively and were significantly higher than that of group B in which the values were 65.71% (23/35) and 77.14% (27/35) respectively. The 5 -year survival rate of group A was 68.57% (24/35 ), while that of group B was merely 40.00% (14/35)and the differences between the two groups were statistically significant (χ²=5.7 P<0.05). The distant metastasis occurrence rate of group B was higher than that of group A (χ²=16.80 P<0.01). II III stage acute toxic side effects of oral mucosa and numeration of leukocyte of group A was more significant than that of group B. Furthermore about one third of patients in group A, Conclusion : Combined radiotherapy and chemotherapy can significantly increase 5-year survival rates and decrease distant metastasis of stage ₂N₂M₀ nasopharyngeal carcinoma. Although the resultant acute toxic effects were not decreased, most patient can endure.