Abstract: Objective : Screening the sensitive related genes to the anti -tumor medicine of NVB and Doc in SCLC and NSCLC cell-lines. M ethod : To determine the sensitivity of 4 lines SCLC and 6 lines NSCLC to NVB and Doc with MTT, to determine the expression of 1291 anti -tumer medicine sensitive related genes among 10 lung cancer cell lines with the technique of cDNA macroarray, and analysis the relativity between above two results. Results : There are 56 sensitive (r ≥± 0.4) related genes to Doc and NVB. 1) There are 36 sensitive related genes to NVB, and there are 20 co-compressive genes in SCLC、 NSCLC set and NSCLC set. There are 27 compressive genes in SCLC、NSCLC set,7 special compressive genes; there are 29 compressive genes in NSCLC set, 9 special compressive genes. 2) There are 50 sensitive related genes to Doc, and there are 12 co-compressive genes in SCLC 、NSCLC set and NSCLC set. There are 24 compression genes in scLC 、 NSCLC set, 12 special compression genes ; there are 38 compression genes in NSCLC set, 26 special compression genes. 3) The sensitive related genes to the anti-tumor medicine of NVB and Doc in lung cancer cell lines are m ainly distributed in the numerators of the signal conduction, the on behalf thanks mediums and their depressants, the factors of cell, the conveyance and copy factors 4 category types. C onclusion : There are obvious difference in the sensitive related genes to NVB and Doc between SCLC cell -lines and NSCLC cell-lines, but their aivided category tvpes are mostly same.