Abstract: objective: To investigate the efficacy and the adverse effects of chronomodulated chemotherapy by 5-FU±LV+DDP in the treatment of advanced nasopharyngeal cancer patients. Methods: From 03/2001 to 01/2003, 30 patients with pathologically diagnosed advanced nasopharyngeal cancer who were never received chemotherapy were included, among which 20 were with locally advanced primary diseases (Induction CT group); 10 with metastatic primary diseases or recurrent and/or metastatic diseases (Induction CT group). Using "Melodie" multi-channel programmed pump made of AGUETTANT company France, the patients received a five-day course of 5-FU LY (5FU 600/m² and LY 200mg/m² for CT group; 5FU 750-850mg/m² without CF for Induction CT group; peak delivery rate at 04:00) and DDP (20mg/m², peak delivery at 16:00). Each course was repeated every 3 weeks. 2 cycles of chemotherapy were given for Induction CT group before radiotherapy and 2 to 6 cycles were given for CT group. Results: For Induction CT group, all were achieved partial response after 2 cycles of neoadjuvant chemotherapy. The complete response were 95% (19/20) after the end of radical radiotherapy. For CT group, Partial Response(PR) was 80%, Stable Disease (SD) was 20%(2/10),and Progression Disease (PD) was 10% (1/10). The main adverse effect is thrombocytopenia which was found in 26.1% of patients (8/30) and 14.1% (13/92) of cycles. Other adverse effects were mild. Conclusions: For advanced nasopharyngeal cancer patients, chronomodulated infusion of 5-FU±LV+DDP can get the treatment effects with minimal adverse effects. Further clinical research is recommended to test its contribution to survival.