Abstract: Objective ： A retrospective study has been made on the microsurgical management of 28 cases of intracranial tumors removed with combined supratentorial and infratentorial approach in our hospital between the year 1992 till now in order to increase the clinical outcome of theses diseases. Methods ： There are 19 male and 9 female with an age between 5~45 years (mean 32.2 years) in this series. All the tumors were located both supratentorially and infratentorially. 23 (82.1L) cases had the symptoms of intracranial hypertension. Another 18(64.3%) cases showed malfunction of acoustic organs.Microsurgical techniques and combined supratentorial and infratentorial approaches have been utilized to remove tumors. Results : 22 cases had total removal and others subtotal resection. The postoperative morbidity is zero. The follow-up study in 10 months to 10 years showed that 24 cases resume normal life and 2 cases with dependent life and 2 with recovery to some extent. Conclusions ： Tumors with supratentorial and infratentorial extension are normally benign ones such as meningiomas and acoustic neuromas. Microsurgical and piecemeal techniques as well as combined supratentorial and infratentorial approaches may increase the possibility to remove tumors totally and result in improved clinical results.