Abstract: Objective: To seek an effective treatment of conventional fraction stereotactic conformal radiotherapy (C F S C R) for advanced pancreatic carcinoma. Methods: patients were treated by CFSCR of 6MYX-ray. Patients were fixed with vac-lok cushion of the device of stereotactic localization. the CT Scanning results of 28 cases of advanced pancreatic carcinoma were put into the treatment planning system. According to the target area of tumor, sensitive organs and moving error drew GTY, CTY and PTY. The best plan was selected in considering the dose -volume histogram. Using 5 to 7 beams of non-coplanar radiation ray were choosed. PTY were surrounded by 80V-90V isodose surves. Conventional fraction, 5 fractions per week, 2 GY per fraction, All patients received a total dose of 60 GY-70GY/42-49 days. Results: In a period of one month to three months, after CFSCR, appetite was improved in 24 of 28 patients (85.7%), jaundice disappeared in 6 of 6 patients(100%), Abdominal pain was relieved in 17 of 28 patients (60.7%) and 8 patients were relieved completely (28.6%). the complete remission of tumor was 35.7% (10/28) and partial remission of tumor was 64.3% (18/28). One-year rate was 76.5%(13/17). As a consequence of cachexia, 4 patients died within 1 year. Conclusion: CFSCR for advanced pancreatic carcinoma may relieve symptomsG It is an effective approach to improve life quality and prolong survival time for advanced pancreatic carcinoma, especially lod and weak patients more suit to select CFSCRG.