王立万, 张进川, 李洪霞. 153例尸检证实8例肺癌与肺血栓栓塞症分析[J]. 中国肿瘤临床, 2004, 31(15): 871-873.
引用本文: 王立万, 张进川, 李洪霞. 153例尸检证实8例肺癌与肺血栓栓塞症分析[J]. 中国肿瘤临床, 2004, 31(15): 871-873.
Wang Li-wan, Zhang Jin-chuan, Li Hong-xia. Pulmonary Thrombembolism ana Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2004, 31(15): 871-873.
Citation: Wang Li-wan, Zhang Jin-chuan, Li Hong-xia. Pulmonary Thrombembolism ana Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2004, 31(15): 871-873.

153例尸检证实8例肺癌与肺血栓栓塞症分析

Pulmonary Thrombembolism ana Lung Cancer

  • 摘要: 目的:提高对肺癌并发肺血栓栓塞症(PTE)的认识。方法:回顾性调查自1980年至2002年间我院连续非选择性常规尸检的153例肺癌死亡患者的尸检病理资料,并对尸检证实合并有PTE的8例进行临床及病理对比分析。结果:1)153例肺癌中8例并发PTE,但生前只有1例确诊,发生率为5.3%(8/153),误诊率87.5%(7/8)。2)尸检发现栓子性质均为血栓。临床3例猝死者为肺主动脉伴左右肺动脉主干血栓栓塞,同时合并下肢深静脉血栓形成及左心室附壁血栓1例;5例非猝死者为肺动脉中小分支血栓栓塞,伴下肢深静脉血栓3例。3)肺癌并发PTE时临床表现不典型。4)PTE主要见于肺腺癌(包括肺泡癌及腺鳞癌),占62.5%(5/8)。结论:PTE并发于肺癌并不少见,但误诊率高,诊断意识缺乏是误诊的主要原因。肺癌并发PTE最主要原因是血液处于高凝状态。

     

    Abstract: Objective : To increase the awareness of lung cancer complicating pulmonary throm-boembolism(PTE). Methods : Routine autopsy pathological data of 1"3 patients died of lung cancer who admitted to PLA General Hospital from 1990 to 2002 were retrospectively investigated, then the clinical and pathological data of 8 patients among them who associated with PTE proved by autopsy were analyzed comparatively. Results : 1) Of the 153 cases, there were 8 cases complicating PTE, but only 1 case was diagnosed based on clinical symptoms and CT during life. The incidence of PTE was 5.3%(8/153), and misdiagnosis rate was 87.5%(7/8). 2) The characteristic of embolus was proved to be throm-bus by autopsy in all 8 cases. The emboli occurred both in the main pulmonary artery (PA) and in the main branch of the left and right PA in 3 sudden death patients, and one of them with deep venous thrombosis (DVT) and mural thrombus in the left ventricle. The thrombi were located in the middle and small branch of PA in the other 5 cases, and three of them with DVT. 3) There were no typical clinicalpresentation in those patients with lung cancer complicating PTE. 4) The most common pathological type of lung cancer complicating PTE was adenocarcinoma. Conclusions : Lung cancer complicating PTE was not unusual owing to hypercoagulation state, but misdiagnosis rate was high due to lack of di- agnostic consciousness of PTE.

     

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