Abstract: Objective: To analyze the clinical characteristics, diagnosis, treatment and prognosis of primary Non-Hodgkin's lymphoma of bone (PLB). Methods: Twenty-one patients diagnosed with PBL in Cancer Hospital Chinese Academy of Medical Sciences between Nov. 1970 and Feb. 2003 were reviewed. Fourteen patients presented with stage I (66.7%), 2 with stage II (9.5%),and 5 with stage IV (23.8%). Twelve patients (57.1%) had a diffuse large B cell lymphoma, four (19.0%) had a mixed cell lymphoma, one (4.8%) had a small lymphocyte lymphoma, one (4.8%) had T cell lymphoma, and three (14.3%) had unclassified Non-Hodgkin's lymphoma. Six patients (28.6%) received radiotherapy alone and fifteen patients (71.4%) received radiotherapy combined chemotherapy. Results: The median follow-up for the whole group was 86 months, two patients (9.5%) had local relapse and nine (42.9%) experienced distant involvement. The disease free survival rates for 3-year, 5-year and 10-year were 56.7%、38.9%、29.1%, respectively. The overall survival rates for 3-year, 5-year and 10-year were 69.1%、42.2%、42.2%, respectively. Conclusions: Combination therapy including radiotherapy and chemotherapy is the optimal treatment for PLB. The recommended dose of radiotherapy is 4500cGy~ 4600cGy.