Abstract: Objectives: To investigate clinical and pathological features of Inflammatory Malignant Fibrous Histiocytoma and its treatment as well as prognosis. Methods: Analyze the three cases of Inflammatory Malignant Fibrous Histiocytoma in our department and literatures from foreign journals. Resaults: Inflammatory Malignant Fibrous Histiocytoma always presents leukemoid reaction symptoms such as fever, WBC counts elevation and mass with poor prognosis. Immunohistochemical examination can improve differentiation of diagnosis. Surgery is an effective treatment while chemotherapy has no remarkable response. Conclusions: Inflammatory Malignant Fibrous Histiocytoma is very rare but a high grade tumor. Early detection and early treatment play the key role in increasing its curability and elongating the patients survival rate.