Abstract: Objective: To study the relationship between YEGF, KDR gene and MYD and prognosis in patients with lung cancer. Methods: The expression of VEGF、KDR gene and MYD were detected in 114 lung cancer tissues by immunohistochemical staining (LSAB Methods). Results: The 5 -year surrvial rate with high expression of YEGF and KDR (18.18% 21.19%) in patients was significantly lower than those with Low YEGF, KDR expression (61.19%, 52.74%)(P<0.01); The 5-year surrvial rate with high MYD group (17.27%) in patients was significantly lower than those with Low MYD group (52.74%)(P<0.01); The survival of patients was negatively related to the expression of YEGF, KDR and MYD (P<0.01); The results of multivariable cox model showed that the pTNM was the most significatly variables for predicting prognosis among the all related factors in lung cancer, But MYD, KDR and YEGF are the more significantly variables. Conclusion: Overexpression of YEGF KDR gene and high MYD may play an important role in the oncogenesis, development of lung cancer; Detection of MYD and expressional of YEGF and KDR might be helpful to predict prognosis in patients with lung cancer.