Abstract: Objectives :To observe the role of recombinant human growth hormone (rhGH) and enteral nutrition (EN) support after gastrointestinal tumor surgery. Methods :Nineteen cases of patients received enteral nutrition and rhGH (experiment group).Twenty-one cases of patients undewrent the same enterral nutrition as experiment group (control group). Results : Befor treating, there was no significant difference between the two groups in the plasma protein (albumin 、preprotein、transferrin)·The level of plasma proteins was increased in the two groups, but the change in experiment group was more significant than that in control group (P<0.05).Score of postoperative fatigue(POF) in experiment group on day 10 after operation was lower significantly than that in control group (P<0.05). Conclusion :combined treatment using rhGH and EN could obviously promote protein synthesis,and the patients with rhGH after gastrointestinal tumor surgery can recover more rapidly from POF.