Abstract: Objective: To observe the effect and side-effect of the treatment of routine radiotherapy combining stereotactic radiotherapy (RRT+SRT) on lung squamous cell cancer. Methods: Thirty patients with lung squamous cell cancer were treated with stereotactic tadiotherapy, DT 42~44Gy, then the residual fows were boosted with stereotactic radiotherapy, which was given by 5~9Gy/fraction,tertian irradiation, DT 25~36Gy. In the same time, another 30 patients with lung squamous cell cancer accepting routine radiotherapy only (RRT) belonged to control group. Results: The effect rate and 1 -year survival rate of RRT+SRT group and RRT group were 86.7%, 86.7%, and 60.0%, 53.3%, respectively. There was significant difference in the two groups (5<0.005), but acute radiation -induced esophagitis and pneumonitis and pulmonary fibrosis didn't have significant difference (5>0.05). Conclusions: Recent effect and 1 -year survival rate of patients with lung squamous cell cancer accepting RRT+SRT is better than that of patients accepting RRT only. So lung squamous cell cancer treated by RRT +SRT may be expected to obtain better effect.