Abstract: Objective :To evaluate the clinical value of CA15-3 measurement in nipple discharge sufferer. Methods :The CA15-3 content in serum of nipple discharge group (divided in cancer group and benign group) was measured by immunochemistry method, and compared with normal group. Results :Mean levels of CA15-3 content in the cancer group (35.5±7.3)U/ml were significantly higher than the benign group O26.2±3.9)U/ml and the normal group (23.1±4.7)U/ml (P<0.05), and the significant differences were also found among the three groups (P<0.05) by comparing the CA15-3 positive rate. Conclusion :The AC15-3 measurement in nipple discharge sufferer may have some clinical value for early diagnose of benign breast disease or cancer.