Abstract: Objective: To observe the effectiveness and safety of transcatheter arterial chemoem-bolization (TACE) combined with partial splenic embolization (PSE) treating primary hepatocelluar car-cinomar (HCC) with hypersplenism. Methods: Thirty patients with liver cirrhosis'portal hypertension and hypersplenism were treated by TACE and PSE to observe the degree for reduction of tumor volume and remission of hypersplenism. Results: Tumor reduction rate of HCC patients was 73.33%. The emission rate in 28 hypersplenism patients was 93.33% and there was no severe complication such as hepatic abscessH Conclusion: TACE combined with PSE is a safe and effective method to treat HCC with liver cirrhosis, portal hypertension and hypersplenism.