Abstract: Objective : To investigate the expression of estrogen receptors (ER) and progesterone receptors (PR) in non-small cell lung cancer and relation with type of pathyology, tumor differentiation and age of the patients. Methods : 66 resected speciments of lung cancer were examined. ER and PR were detected using immunohistochemical staining. Results : The overall positive rate for ER were 59.3%, and 62.5% for PR. In squamas carcinoma, 56.% were positive for both ER and PR. In adenocarcinoma 62.5 % were positive for ER and 71.8% for PR. There was a significant correlation between ER and PR positive percentage and degrees of histological differentiation in lung cancer, while ER and PR percentage appears to have no relationship with histological type, age and sex of patients. Conclusions : it is clear that ER and PR are present in non-small cell lung cancer. These result may provide a basis for adjuvant therapy in lung cancer patients.