Abstract: Objective: In this study, an attempt was made to explore correlations of microvessel density (MYD) with the prognosis of axillary-node-negative breast carcinoma(ANNBC). Methodes: Microvessel density was measured by an immunohistochemical technique. Results was analyzed by both univariate and multivariate statistical analysis to ensure the correlation of MYD with the clinical pathologic agents, disease-free survival and overall survival rates in patients with ANNBC. Results: MYD had no relevance with the clinical pathology factors (age, endocrine status and hormone receptor level), but it was apparently valuable in evaluating DFS and OS of ANNBC patients. Conclusion: Micro-vessel density is independent prognostic indicator of failure that is useful in selection of high-risk ANNBC patients for adjuvant therapies.