Abstract:
Objective :To explore the expression of STAT3 and several main subtribes of MAPK in non-small cell lung cancer (NSCLC),the relationship among these signal transduction proteins,and their influence on prognosis of non-small cell lung cancer.
Methods :Seventy-one paraffin sections of patients between 1996 and 1997 were studied using immunohistochemistry to clarified the expression of these several proteins.
Results :The expression of p38,ERK1 and STAT3 was associated with clinical staging (
P<0.01);and JNK1 with tumor location (
P=0.028) and clinical staging (
P=0.000).There was a correlation between p38 and STAT3 (
P=0.000).The expression of STAT3 (
P=0.0006),p38 (
P=0.000 0) and JNK1 (
P=0.0208),tumor differentiation (
P=0.0059) and clinical staging (
P=0.0000) were significantly correlated with prognosis of non-small cell lung cancer by univariate analysis,and STAT3 (
P= 0.025),p38 (
P=0.026),tumor differentiation (
P=0.003),and clinical staging (
P=0.019) were correlated with prognosis by multivariable analysis.Using p38 and STAT3 together,we found that the negative expression of both p38 and STAT3 linked with better prognosis of NSCLC (
P<0.05).
Conclusion :Of several proteins in the two signal transduction pathways,the expression of STAT3 can motivate that of p38,and the expression of these two proteins can help to predict the prognosis of NSCLC.